Biallelic Gene Targeting in Rice

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Biallelic Gene Targeting in Rice1[OPEN]

Plant Genome Engineering Research Unit, Agrogenomics Research Center, National Institute of Agrobiological Sciences, 2-1-2 Kannondai, Tsukuba, Ibaraki, 305-8602, Japan (M.E., M.M., S.T.); Graduate School of Nanobioscience, Yokohama City University, 22-2 Seto, Kanazawa-ku, Yokohama, Kanagawa, 236-0027, Japan (M.M., S.T.); and Kihara Institute for Biological Research, Yokohama City University, 64...

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The modification of an endogenous gene into a designed sequence by homologous recombination, termed gene targeting, has broad implications for basic and applied research. Rice (Oryza sativa L.), with a sequenced genome of 389 Mb, is one of the most important crops and a model plant for cereals, and the single-copy gene Waxy on chromosome 6 has been modified with a frequency of 1% per surviving ...

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Gene targeting (GT) refers to the designed modification of genomic sequence(s) through homologous recombination (HR). GT is a powerful tool both for the study of gene function and for molecular breeding. However, in transformation of higher plants, non-homologous end joining (NHEJ) occurs overwhelmingly in somatic cells, masking HR-mediated GT. Positive-negative selection (PNS) is an approach f...

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ژورنال

عنوان ژورنال: Plant Physiology

سال: 2015

ISSN: 0032-0889,1532-2548

DOI: 10.1104/pp.15.01663